Comparison of methods for determining the partition coefficient of gadolinium in the myocardium using T1 mapping. Issue 1 (29th November 2012)

• Record Type: Journal Article
• Authors: Salerno, Michael; Janardhanan, Rajesh; Jiji, Ronny S.; Brooks, Jeremy; Adenaw, Nebiyu; Mehta, Bhairav; Yang, Yang; Antkowiak, Patrick; Kramer, Christopher M.; Epstein, Frederick H.
• Is Part Of: Journal of magnetic resonance imaging. Volume 38:Issue 1(2013)
• Page Start: 217
• Page End: 224
• Publication Date: 2012-11-29
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.23875
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri23875-sec-0001" sec-type="section"> <title>Purpose</title> <p>To develop and validate modified Look‐Locker (MOLLI) protocols to generate myocardial T<sub>1</sub> maps within clinically acceptable breath‐hold durations and to compare partition coefficients (λ) of gadolinium (Gd)‐DTPA determined from either bolus injection (BI) or continuous infusion (CI) techniques.</p> </sec> <sec id="jmri23875-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>T<sub>1</sub> mapping was performed in phantoms and in 10 volunteers on a 1.5T scanner using the standard (3‐3‐5) MOLLI technique and two MOLLI schemes with shorter breath‐hold durations. Imaging was performed precontrast and every 5 minutes following a bolus of 0.1 mmol/kg Gd‐DTPA and a 15‐minute delayed continuous infusion of 0.001 mmol/kg Gd‐DTPA until equilibrium T<sub>1</sub> in the myocardium was achieved to enable direct comparison of T<sub>1</sub> relaxation times between techniques and λ's between the BI and CI methods.</p> </sec> <sec id="jmri23875-sec-0003" sec-type="section"> <title>Results</title> <p>There was good agreement of T<sub>1</sub> values between the 3‐3‐5 standard MOLLI protocol and the modified 3‐5 MOLLI protocol in both phantom studies over a range of heart rates and in human subjects. Both MOLLI protocols produced similar measurements of λ using both the BI and CI methods.</p> </sec> <sec id="jmri23875-sec-0004" sec-type="section"> <title>Conclusion</title> <p>A reduced breath‐hold MOLLI T<sub>1</sub> mapping protocol combined with the BI method can accurately characterize T<sub>1</sub> and λ in clinically applicable breath‐hold durations without requiring a long equilibrium phase infusion. J. Magn. Reson. Imaging 2013;38:217–224. © 2012 Wiley Periodicals, Inc.</p> </sec> </abstract>