Study on Noninvasive Laboratory Tests for Fibrosis in Chronic HBV Infection and Their Evaluation. Issue 1 (4th January 2013)

• Record Type: Journal Article
• Authors: Chen, Jing; Liu, Can; Chen, Huijuan; Liu, Qicai; Yang, Bin; Ou, Qishui
• Is Part Of: Journal of clinical laboratory analysis. Volume 27:Issue 1(2013:Jan.)
• Page Start: 5
• Page End: 11
• Publication Date: 2013-01-04
• Subjects: Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.21554
• Languages: English
• ISSNs: 0887-8013

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jcla21554-sec-0010" sec-type="section"> <title>Background</title> <p>Noninvasive laboratory tests have been widely used in the diagnosis of liver fibrosis. This study was designed to evaluate the diagnostic value of the four serum markers detected on a JETLIA‐962 chemiluminescence analyzer and the FibroTest index for chronic hepatitis B (CHB) related liver fibrosis. J. Clin. Lab. Anal. 27:5–11, 2013. © 2012 Wiley Periodicals, Inc.</p> </sec> <sec id="jcla21554-sec-0020" sec-type="section"> <title>Methods</title> <p>A JETLIA‐962 chemiluminescence analyzer was used to measure the hyaluronic acid (HA), laminin (LN), procollagen III N‐terminal peptide (PIIINP), and type IV collagen (CIV) contents in the sera of CHB patients and controls.</p> </sec> <sec id="jcla21554-sec-0030" sec-type="section"> <title>Results</title> <p>In our research, it was found that serum HA, LN, PIIINP, and CIV concentrations and the FibroTest index were correlated with fibrosis stage. The FibroTest index had the largest area under the receiver operating characteristic (ROC) curve for fibrosis and cirrhosis (0.80 and 0.776, respectively). The five indices together were able to exclude fibrosis with a negative likelihood ratio <0.1. The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were separately established.</p> </sec> <sec id="jcla21554-sec-0040" sec-type="section"> <title>Conclusions</title> <p>We found that the JETLIA‐962 chemiluminescence analyzer was of great value in diagnosis of liver fibrosis. Combining five indices improved the diagnostic efficiency and reduced the incidences of unnecessary liver biopsies. Two logistic regression equations established may be helpful in diagnosing liver fibrosis and early cirrhosis, which need to be further evaluated.</p> </sec> </abstract>