AKT primes snail‐induced EMT concomitantly with the collective migration of squamous cell carcinoma cells. Issue 9 (18th July 2013)

• Record Type: Journal Article
• Authors: Okui, Gaku; Tobiume, Kei; Rizqiawan, Andra; Yamamoto, Kazuhiro; Shigeishi, Hideo; Ono, Shigehiro; Higashikawa, Koichiro; Kamata, Nobuyuki
• Is Part Of: Journal of cellular biochemistry. Volume 114:Issue 9(2013:Sep.)
• Page Start: 2039
• Page End: 2049
• Publication Date: 2013-07-18
• Subjects: Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.24545
• Languages: English
• ISSNs: 0730-2312

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jcb24545-sec-0001" sec-type="section"> <p>In this study, we found that wounding of a confluent monolayer of squamous cell carcinoma (SCC) cells induced epithelial–mesenchymal transition (EMT) specifically at the edge of the wound. This process required the combined stimulation of TGFβ, TNFα, and PDGF‐D. Such a combined cytokine treatment of confluent monolayers of the cells upregulated the expression levels of Snail and Slug via PI3K. The PI3K downstream effector, AKT, was dispensable for the upregulation of Snail and Slug, but essential for enabling EMT in response to upregulation of Snail and Slug. J. Cell. Biochem. 114: 2039–2049, 2013. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>