Netrin‐1 Pretreatment Protects Rat Kidney against Ischemia/Reperfusion Injury via Suppression of Oxidative Stress and Neuropeptide Y Expression. Issue 4 (18th January 2013)

• Record Type: Journal Article
• Authors: Liu, Ling; Xie, Shuqin; Liao, Xiaohui; Zhang, Ling; Zhong, Ling
• Is Part Of: Journal of biochemical and molecular toxicology. Volume 27:Issue 4(2013:Apr.)
• Page Start: 231
• Page End: 236
• Publication Date: 2013-01-18
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Toxicology -- Periodicals; 574
• DOI: 10.1002/jbt.21474
• Languages: English
• ISSNs: 1095-6670

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Netrin‐1 has been found to protect kidneys from ischemia/reperfusion injury. In this study, we aimed to address whether the protective effects were mediated through suppression of oxidative stress and neuropeptide Y. Compared to sham‐operated animals, animals after ischemia/reperfusion showed marked kidney damage and significantly increased levels of serum creatinine, blood urea nitrogen, malondialdehyde, and neuropeptide Y. Renal myeloperoxidase activity was elevated in animals with ischemia/reperfusion relative to sham‐operated animals, whereas renal superoxide dismutase activity was reduced. Netrin‐1 pretreatment attenuated ischemia/reperfusion‐induced functional and pathological changes in the kidney. Moreover, the ischemia/reperfusion‐induced changes in the oxidative stress biomarkers and neuropeptide Y were significantly counteracted by prior administration of netrin‐1. Taken together, our data showed that netrin‐1 pretreatment prevented renal ischemia/reperfusion injury, at least partially through reduction of oxidative stress and neuropeptide Y expression. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:231‐236, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21474</p> </abstract>