Delineating breast ductal carcinoma using combined dye‐enhanced wide‐field polarization imaging and optical coherence tomography. Issue 9 (25th September 2012)

• Record Type: Journal Article
• Authors: Patel, Rakesh; Khan, Ashraf; Kamionek, Michal; Kandil, Dina; Quinlan, Robert; Yaroslavsky, Anna N.
• Is Part Of: Journal of biophotonics. Volume 6:Issue 9(2013:Sep.)
• Page Start: 679
• Page End: 686
• Publication Date: 2012-09-25
• Subjects: Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201200102
• Languages: English
• ISSNs: 1864-063X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Intra‐operative delineation of breast cancer is a challenging problem. We used dye‐enhanced wide‐field polarization imaging for rapid demarcation of <italic>en face</italic> cancer margins and optical coherence tomography (OCT) for cross‐sectional evaluation. Ductal carcinoma specimens were stained with methylene blue. Wide‐field reflectance images were acquired at 440 and 640 nm. Wide‐field fluorescence images were excited at 640 nm and registered between 660 nm and 750 nm. OCT images were acquired using a 1310 nm swept‐source system. The results were validated against histopathology. Both imaging modalities provided diagnostic information on cancer margins. Combined OCT and wide‐field polarization imaging shows promise for intra‐operative detection of ductal breast carcinoma (© 2013 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)</p> </abstract>