Cover Picture: ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function / JSmol and the Next‐Generation Web‐Based Representation of 3D Molecular Structure as Applied to Proteopedia (Isr. J. Chem. 3‐4/2013). Issue 3 (15th April 2013)

• Record Type: Journal Article
• Authors: Celniker, Gershon; Nimrod, Guy; Ashkenazy, Haim; Glaser, Fabian; Martz, Eric; Mayrose, Itay; Pupko, Tal; Ben‐Tal, Nir; Hanson, Robert M.; Prilusky, Jaime; Renjian, Zhou; Nakane, Takanori; Sussman, Joel L.
• Is Part Of: Israel journal of chemistry. Volume 53:Issue 3/4(2013)
• Page Start: 137
• Page End: 137
• Publication Date: 2013-04-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/ijch.201390002
• Languages: English
• ISSNs: 0021-2148

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The cover shows on the left a ConSurf analysis of the influenza neuraminidase protein. The 3D tetramer colored by conservation grades is shown in (A) with maroon indicating the most conserved amino acids, and close‐up views (B, C) are shown of one of the conserved regions with the anti‐flu drug, oseltamivir (tamiflu) bound; see Celniker et al. for details, <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 199</ext-link>. On the right is a page from Proteopedia as viewed on an iPad, via the JSmol viewer, showing a complex of HIV‐Protease and Saquinavir (Invirase), the first protease inhibitor approved by the FDA for the treatment of HIV; see Hanson et al. for details, <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 207</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xqhprjv" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>