Reflecting on Earlier Experiences with Unsolicited Findings: Points to Consider for Next‐Generation Sequencing and Informed Consent in Diagnostics. Issue 10 (16th July 2013) - Rigter, Tessel
Abstract High‐throughput nucleotide sequencing is increasingly being used in clinical diagnostics. The increased chance of detecting unsolicited findings requires decisions on disclosure of these findings and poses a challenge for the informed consent procedure. This article discusses the ethical and practical dilemmas encountered when contemplating informed consent for next generation sequencing in diagnostics from a multidisciplinary point of view. We hereby aim to provide a sound basis for developing guidelines for optimizing the informed consent procedure