DIP–STR: Highly Sensitive Markers for the Analysis of Unbalanced Genomic Mixtures. Issue 4 (5th March 2013)

• Record Type: Journal Article
• Authors: Castella, Vincent; Gervaix, Joëlle; Hall, Diana
• Is Part Of: Human mutation. Volume 34:Issue 4(2013:Apr.)
• Page Start: 644
• Page End: 654
• Publication Date: 2013-03-05
• Subjects: Human chromosome abnormalities -- Periodicals; Mutation (Biology) -- Periodicals; 616.04205
• DOI: 10.1002/humu.22280
• Languages: English
• ISSNs: 1059-7794

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="humu22280-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Here we propose a new genetic marker, named DIP‐STR that enables the analysis of DNA mixtures containing highly unbalanced proportions of DNA from two individuals. This new tool is characterized by several remarkable features: (1) capacity of detecting a minor DNA contributing less than 0.1%; (2) equal performances regardless the sex of the DNA donors; (3) high discrimination power for identity testing; finally (4) simple and low cost genotyping technique. Applications may include forensics, prenatal diagnosis and organ transplant monitoring. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v7r2nm9" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>