Somatic Alterations Contributing to Metastasis of a Castration‐Resistant Prostate Cancer. Issue 9 (3rd June 2013)

• Record Type: Journal Article
• Authors: Nickerson, Michael L.; Im, Kate M.; Misner, Kevin J.; Tan, Wei; Lou, Hong; Gold, Bert; Wells, David W.; Bravo, Hector C.; Fredrikson, Karin M.; Harkins, Timothy T.; Milos, Patrice; Zbar, Berton; Linehan, W. Marston; Yeager, Meredith; Andresson, Thorkell; Dean, Michael; Bova, G. Steven
• Is Part Of: Human mutation. Volume 34:Issue 9(2013:Sep.)
• Page Start: 1231
• Page End: 1241
• Publication Date: 2013-06-03
• Subjects: Human chromosome abnormalities -- Periodicals; Mutation (Biology) -- Periodicals; 616.04205
• DOI: 10.1002/humu.22346
• Languages: English
• ISSNs: 1059-7794

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="humu22346-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We sequenced the exomes of five metastatic tumors and healthy kidney tissue from a mCRPC index case to identify lesions associated with disease progression and metastasis. The majority of somatic nonsynonymous variants were present in all metastases and only a subset was observed in the primary tumor. Somatic variants in individual tumors permitted us to infer a chronology for the clonal spread of disease based on sequential accrual of lesions. <italic>TET2</italic> alteration or loss may define a subset of mCRPC. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg372673r8" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>