Divergent Enantioselective Total Synthesis of Siphonarienal, Siphonarienone, and Pectinatone. Issue 10 (16th October 2013)

• Record Type: Journal Article
• Authors: Yadav, Jhillu Singh; Chary, D. Narasimha; Yadav, Nagendra Nath; Sengupta, Sandip; Subba Reddy, Basi V.
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 10(2013:Oct.)
• Page Start: 1968
• Page End: 1977
• Publication Date: 2013-10-16
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201300035
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A divergent synthesis of siphonarienal, siphonarienone, and pectinatone has been achieved from a common precursor <bold>4</bold>, which was synthesized by using an enzymatic desymmetrization approach. The major key steps involved were <italic>Grignard</italic> reaction, <italic>Wittig</italic> reaction, <italic>Evans</italic>' asymmetric alkylation, and base‐catalyzed cyclization.</p> </abstract>