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A Copper‐Catalyzed Multicomponent Reaction and 'Click Strategy' for the Stereoselective Synthesis of a New Series of Oxazolone Peptidomimetics with α‐Acylamino Amide and β‐Amido Ketone Structures. Issue 12 (December 2013)
Record Type:
Journal Article
Title:
A Copper‐Catalyzed Multicomponent Reaction and 'Click Strategy' for the Stereoselective Synthesis of a New Series of Oxazolone Peptidomimetics with α‐Acylamino Amide and β‐Amido Ketone Structures. Issue 12 (December 2013)
Main Title:
A Copper‐Catalyzed Multicomponent Reaction and 'Click Strategy' for the Stereoselective Synthesis of a New Series of Oxazolone Peptidomimetics with α‐Acylamino Amide and β‐Amido Ketone Structures
<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel 'click ligation' strategy for the stereoselective synthesis of a medium‐size library of structurally complex and functionally diverse oxazolone peptidomimetics, which contain <italic>α</italic>‐acylamino carboxamide or <italic>β</italic>‐amido ketone residues, is presented. Most of these molecules have lipophilicity constant values (log <italic>P</italic>) in the qualifying range for cell permeability, and that indicates the possibilities of these new molecules to be used in the search for potential inhibitors for a broad spectrum of enzymes.</p> </abstract>