A Copper‐Catalyzed Multicomponent Reaction and 'Click Strategy' for the Stereoselective Synthesis of a New Series of Oxazolone Peptidomimetics with α‐Acylamino Amide and β‐Amido Ketone Structures. Issue 12 (December 2013)

• Record Type: Journal Article
• Authors: Balan, Biny; Bahulayan, Damodaran
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 12(2013:Dec.)
• Page Start: 2251
• Page End: 2266
• Publication Date: 2013-12
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201300057
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel 'click ligation' strategy for the stereoselective synthesis of a medium‐size library of structurally complex and functionally diverse oxazolone peptidomimetics, which contain <italic>α</italic>‐acylamino carboxamide or <italic>β</italic>‐amido ketone residues, is presented. Most of these molecules have lipophilicity constant values (log <italic>P</italic>) in the qualifying range for cell permeability, and that indicates the possibilities of these new molecules to be used in the search for potential inhibitors for a broad spectrum of enzymes.</p> </abstract>