One‐Pot Synthesis of Dispiro[oxindole‐3, 3′‐pyrrolidines] by Three‐Component [3+2] Cycloadditions of in situ‐Generated Azomethine Ylides with 3‐Benzylidene‐2, 3‐dihydro‐1H‐indol‐2‐ones. Issue 11 (November 2013)

• Record Type: Journal Article
• Authors: Matloubi Moghaddam, Firouz; Kiamehr, Mostafa; Reza Khodabakhshi, Mohammad; Jebeli Javan, Marjan; Fathi, Shaghayegh; Villinger, Alexander; Iaroshenko, Viktor O.; Langer, Peter
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 11(2013:Nov.)
• Page Start: 2103
• Page End: 2114
• Publication Date: 2013-11
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201200602
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An efficient one‐pot, three‐component synthesis of novel dispiro[oxindole‐3, 3′‐pyrrolidines] by 1, 3‐dipolar cycloaddition of azomethine ylides, <italic>in situ</italic> generated by reaction of 1, 2‐diones with sarcosine and subsequent decarboxylation, with a series of (<italic>E</italic>)‐3‐benzylidene‐2, 3‐dihydro‐1<italic>H</italic>‐indol‐2‐ones is reported. Molecular complexity is generated in only one synthetic step. All reactions proceed with excellent regioselectivity and in good‐to‐excellent yields. The workup is easy, the reaction times are short, and no catalyst is required.</p> </abstract>