Natural (−)‐Vasicine as a Novel Source of Optically Pure 1‐Benzylpyrrolidin‐3‐ol. Issue 5 (17th May 2013)

• Record Type: Journal Article
• Authors: Aga, Mushtaq A.; Kumar, Brijesh; Rouf, Abdul; Shah, Bhahwal A.; Andotra, Samar S.; Taneja, Subhash C.
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 5(2013:May)
• Page Start: 969
• Page End: 977
• Publication Date: 2013-05-17
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201200307
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A facile and scalable methodology for the preparation of optically active (3<italic>S</italic>)‐1‐benzylpyrrolidin‐3‐ol (<bold>3</bold>), an important drug precursor, is reported. Starting from the naturally occurring alkaloid (−)‐vasicine (<bold>1</bold>), a major alkaloid of the plant <italic>Adhatoda vasica</italic>, <bold>3</bold> was obtained in 84% overall yield (<italic>Scheme 3</italic>).</p> </abstract>