Organic Stereochemistry. Part 61. Issue 6 (19th June 2013)

• Record Type: Journal Article
• Authors: Vistoli, Giulio; Testa, Bernard; Pedretti, Alessandro
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 6(2013:Jun.)
• Page Start: 1005
• Page End: 1030
• Publication Date: 2013-06-19
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201200474
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Following the previous <italic>Part</italic> on the mechanisms of chiral recognition in pharmacology, the road was open to cover one aspect of stereoselectivity that had been evoked in <italic>Part 5</italic> but not discussed explicitly, namely the pharmacological significance of the conformational behavior of active molecules. There, we saw how ligands and binding sites adapt to each other, but these results were not related explicitly to the conformational behavior of the ligand. The focus of the present <italic>Part</italic> is to use a few well‐known drugs, examine their conformational behavior, compare the 3D geometry of probable conformers with rigid analogs acting at the same receptor, and reflect on the concept of 'active conformation'.</p> </abstract>