Nigerasterols A and B, Antiproliferative Sterols from the Mangrove‐Derived Endophytic Fungus Aspergillus niger MA‐132. Issue 6 (19th June 2013)

• Record Type: Journal Article
• Authors: Liu, Dong; Li, Xiao‐Ming; Li, Chun‐Shun; Wang, Bin‐Gui
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 6(2013:Jun.)
• Page Start: 1055
• Page End: 1061
• Publication Date: 2013-06-19
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201200332
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Two new 6, 8(14), 22‐hexadehydro‐5<italic>α</italic>, 9<italic>α</italic>‐epidioxy‐3, 15‐dihydroxy sterols, nigerasterols A and B (<bold>1</bold> and <bold>2</bold>, resp.), together with two known cyclopentapeptides, malformins A₁ and C (<bold>3</bold> and <bold>4</bold>, resp.), were identified in the culture extract of <italic>Aspergillus niger</italic> MA‐132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant <italic>Avicennia marina.</italic> The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound <bold>1</bold> was determined by application of a modified version of <italic>Mosher</italic>'s method. Nigerasterols A and B (<bold>1</bold> and <bold>2</bold>, resp.) represent the first 5, 9‐epidioxy‐sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay.</p> </abstract>