Crotofolane‐ and Casbane‐Type Diterpenes from Croton argyrophyllus. Issue 6 (19th June 2013)

• Record Type: Journal Article
• Authors: e Silva Filho, Francisco Artur; Nunes da Silva Junior, José; Braz‐Filho, Raimundo; de Simone, Carlos Alberto; Silveira, Edilberto Rocha; Lima, Mary Anne Sousa
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 6(2013:Jun.)
• Page Start: 1146
• Page End: 1154
• Publication Date: 2013-06-19
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201200347
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Phytochemical analysis of <italic>Croton argyrophyllus</italic> led to the isolation of five new diterpenes named (5<italic>β</italic>, 6<italic>β</italic>)‐5, 6 : 13, 16‐diepoxycrotofola‐4(9), 10(18), 13, 15‐tetraen‐1‐one (<bold>1</bold>), (5<italic>β</italic>, 6<italic>β</italic>)‐5, 6 : 13, 16‐diepoxy‐2‐epicrotofola‐4(9), 10(18), 13, 15‐tetraen‐1‐one (<bold>2</bold>), (5<italic>β</italic>, 6<italic>β</italic>)‐5, 6 : 13, 16‐diepoxy‐16‐hydroxy‐2‐epicrotofola‐4(9), 10(18), 13, 15‐tetraen‐1‐one (<bold>3</bold>), (5<italic>β</italic>, 6<italic>β</italic>)‐5, 6 : 13, 16‐diepoxy‐16‐hydroxy‐2‐epicrotofola‐4(9), 10(18), 13, 15‐tetraen‐1‐one (<bold>4</bold>) and (2<italic>E</italic>, 5<italic>β</italic>, 6<italic>E</italic>, 12<italic>E</italic>)‐<italic>5‐</italic>hydroxycasba‐2, 6, 12‐trien‐4‐one (<bold>5</bold>), in addition to the known diterpenes crotonepetin and depressin, and acetylaleuritolic acid and spinasterol. The structures of the isolated compounds were established by a combination of spectroscopic methods, including HR‐ESI‐MS, 2D‐NMR, and X‐ray crystallography.</p> </abstract>