Doped Nano‐Sized Copper(I) Oxide (Cu2O) on MelamineFormaldehyde Resin: a Highly Efficient Heterogeneous Nano Catalyst for 'Click' Synthesis of Some Novel 1H‐1, 2, 3‐Triazole Derivatives Having Antibacterial Activity. Issue 4 (10th April 2013)

• Record Type: Journal Article
• Authors: Rad, Mohammad Navid Soltani; Behrouz, Somayeh; Movahedian, Abdollah; Doroodmand, Mohammad Mahdi; Ghasemi, Younes; Rasoul‐Amini, Sara; Gandomani, Abdol‐Rasoul Ahmadi; Rezaie, Ramin
• Is Part Of: Helvetica chimica acta. Volume 96:Issue 4(2013:Apr.)
• Page Start: 688
• Page End: 701
• Publication Date: 2013-04-10
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201200224
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A facile and simple protocol for the 1, 3‐dipolar cycloaddition of organic azides with terminal alkynes catalyzed by doped nano‐sized Cu₂O on melamineformaldehyde resin (nano‐Cu₂OMFR) as a new and convenient heterogeneous catalyst is described. In this method, 'click' cycloaddition of various structurally diverse <italic>β</italic>‐azido alcohols and alkynes in the presence of nano‐Cu₂OMFR in H₂O/THF 1 : 2 furnished the corresponding 1, 4‐disubstituted 1<italic>H</italic>‐1, 2, 3‐triazole adducts <bold>1a</bold>–<bold>1o</bold> in good to excellent yields at room temperature (<italic>Scheme</italic> and <italic>Table 3</italic>). The nano‐Cu₂OMFR was characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), inductively coupled plasma (ICP) analysis, and FT‐IR. The nano‐Cu₂OMFR could be easily recovered and recycled from the reaction mixture and reused for many consecutive trials without significant decrease in activity (<italic>Table 4</italic>). The <italic>in vitro</italic> antibacterial activities of all synthesized compounds were tested on several <italic>Gram</italic>‐positive and/or <italic>Gram</italic>‐negative bacteria (<italic>Table 5</italic>). The results demonstrate the promising antibacterial activity for some of the synthesized compounds.</p> </abstract>