Clinical outcomes of patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesions. Issue 12 (9th March 2013)

• Record Type: Journal Article
• Authors: Ryu, In Sun; Roh, Jong‐Lyel; Cho, Kyung‐Ja; Lee, Sang‐wook; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon
• Is Part Of: Head & neck. Volume 35:Issue 12(2013:Dec.)
• Page Start: 1764
• Page End: 1770
• Publication Date: 2013-03-09
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23228
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hed23228-sec-0001" sec-type="section"> <title>Background</title> <p>We compared clinical outcomes between patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesion and properly diagnosed as malignant lesion.</p> </sec> <sec id="hed23228-sec-0002" sec-type="section"> <title>Methods</title> <p>The outcomes were compared between patients with benign lesion and malignant lesion (44 each) on preoperative fine‐needle aspiration cytology diagnosis who underwent conservative or radical surgery.</p> </sec> <sec id="hed23228-sec-0003" sec-type="section"> <title>Results</title> <p>Five‐year lesion‐free survival (DFS) rates were 86.8% for benign lesion and 76.3% for malignant lesion (<italic>p</italic> = .128). Surgical extent did not significantly affect locoregional recurrence and DFS (<italic>p</italic> = .360). Univariate analysis showed that sublingual gland tumor, positive resection margin, and extraparenchymal extension (EPE) were significantly associated with DFS (<italic>p</italic> < .05 each). On multivariate analysis, EPE remained an independent variable (<italic>p</italic> = .047, hazard ratio = 6.621, 95% confidence interval = 1.393–31.474).</p> </sec> <sec id="hed23228-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The clinical outcomes of patients with salivary gland carcinomas misdiagnosed as benign are relatively favorable. Conservative surgery may be sufficient for patients with low‐grade and T1–2 salivary gland carcinomas. © 2013 Wiley Periodicals, Inc. <italic>Head Neck</italic> 35: 1764–1770, 2013</p> </sec> </abstract>