Lessons learned from next‐generation sequencing in head and neck cancer1. Issue 3 (21st August 2012)

• Record Type: Journal Article
• Authors: Loyo, Myriam; Li, Ryan J.; Bettegowda, Chetan; Pickering, Curtis R.; Frederick, Mitchell J.; Myers, Jeffrey N.; Agrawal, Nishant; Myers, Jeffrey N.; Ferris, Robert L.
• Is Part Of: Head & neck. Volume 35:Issue 3(2013:Mar.)
• Page Start: 454
• Page End: 463
• Publication Date: 2012-08-21
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23100
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next‐generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in <italic>NOTCH1</italic>, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: <italic>TP53</italic>, <italic>NOTCH1</italic>, <italic>HRAS</italic>, <italic>PIK3CA</italic>, and <italic>CDKN2A</italic>. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</p> </abstract>