Paclitaxel‐based chemotherapy for aggressive kaposiform hemangioendothelioma of the temporomastoid region: Case report and review of the literature. Issue 8 (21st August 2012)

• Record Type: Journal Article
• Authors: Funato, Michinori; Fukao, Toshiyuki; Sasai, Hideo; Hori, Tomohiro; Terazawa, Daisuke; Kanda, Kaori; Ozeki, Michio; Mizuta, Keisuke; Hirose, Yoshinobu; Kaneko, Hideo; Kondo, Naomi; Irish MD, FRCSC, Jonathan
• Is Part Of: Head & neck. Volume 35:Issue 8(2013:Aug.)
• Page Start: E258
• Page End: E261
• Publication Date: 2012-08-21
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23107
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy and childhood. This tumor results in poor prognosis, and therefore, development of a more effective treatment is needed.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods and Results</title> <p>We describe an 11‐year‐old boy presenting with left facial palsy caused by aggressive KHE of the left temporomastoid region. He was treated with paclitaxel‐based chemotherapy, because of the difficulty with complete surgical resection for anatomic factor, multiple lung metastases on diagnosis, and no response to conventional treatments. This treatment reduced the volume of primary tumor and lung metastatic lesions, but the efficacy was transitory.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Conclusions</title> <p>Paclitaxel‐based chemotherapy for aggressive KHE may be effective, therefore the multimodality therapy including paclitaxel of aggressive KHE, particularly in the head and neck, needs to be investigated in further studies. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</p> </sec> </abstract>