Node‐positive hypopharyngeal cancer treated by (chemo)radiotherapy: Impact of up‐front neck dissection on outcome, toxicity, and quality of life. Issue 9 (21st August 2012)

• Record Type: Journal Article
• Authors: Al‐Mamgani, Abrahim; Meeuwis, Cees A.; van Rooij, Peter H.; Mehilal, Robert; Basdew, Harie; Sewnaik, Aniel; Levendag, Peter C.
• Is Part Of: Head & neck. Volume 35:Issue 9(2013:Sep.)
• Page Start: 1278
• Page End: 1286
• Publication Date: 2012-08-21
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23109
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>To investigate the impact of up‐front neck dissection on the outcome of patients with node‐positive hypopharyngeal cancer (HPC) treated with (chemo)radiation.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>Of 135 consecutive patients with node‐positive HPC, 32 patients underwent up‐front neck dissection followed by (chemo)radiation (group 1), and 103 patients received definitive (chemo)radiation (group 2).</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>The 3‐year regional, local and distant control for groups 1 and 2 were 92% versus 87% (<italic>p</italic> = .37), 84% versus 72% (<italic>p</italic> = .15), and 80% versus 62% (<italic>p</italic> = .08), respectively. High T classification was the only significant predictor for poor overall survival on multivariate analysis (OR = 3.0, <italic>p</italic> = .02). Acute and late toxicities and the prospectively assessed quality of life were comparable in both groups.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion</title> <p>Upfront neck dissection followed by (chemo)radiation did not negatively impact on oncologic outcomes, toxicity, or quality of life and therefore is to be regarded as a safe and effective treatment option for small HPC with bulky nodal disease, especially in busy radiation departments with unacceptably long waiting time for definitive (chemo)radiation. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</p> </sec> </abstract>