Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer1. Issue 8 (23rd June 2012)

• Record Type: Journal Article
• Authors: Cartmill, Bena; Cornwell, Petrea; Ward, Elizabeth; Davidson, Wendy; Nund, Rebecca; Bettington, Catherine; Rahbari, Reza Masoud; Poulsen, Michael; Porceddu, Sandro; Myers, Jeffrey N.; Myers, Jeffrey N.
• Is Part Of: Head & neck. Volume 35:Issue 8(2013:Aug.)
• Page Start: 1211
• Page End: 1219
• Publication Date: 2012-06-23
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23040
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>Research has reported relationships between 3‐dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary. The current study aimed to identify which reported dose constraints identified functional impairment at 6 months posttreatment.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>Dose constraints with reported relationships to swallowing and nutrition were identified through a systematic literature review. Dose–volume histograms for 12 patients with T1–T3 oropharyngeal cancer treated with 3D conformal radiotherapy determined dosages delivered to specific structures. Doses were examined in relation to published dose constraints and the swallowing and nutritional outcomes at 6 months posttreatment.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>In all, 66% of the reported mean, maximum, and partial doses to 8 structures correctly identified swallowing and nutrition outcomes at 6 months.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion</title> <p>The relationships observed between known dosimetric constraints and functional outcomes highlight the potential for dosimetric data to assist in prognosis and treatment. Systematic research is required to refine dosimetric parameters and the impact on functional outcomes. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</p> </sec> </abstract>