BRAFV600E mutation in fine‐needle aspiration aspirates: Association with poorer prognostic factors in larger papillary thyroid carcinomas. Issue 4 (7th April 2012)

• Record Type: Journal Article
• Authors: Lee, Ji In; Jang, Hye Won; Kim, Sun Wook; Kim, Jong–Won; Oh, Young Lyun; Chung, Jae Hoon
• Is Part Of: Head & neck. Volume 35:Issue 4(2013:Apr.)
• Page Start: 548
• Page End: 553
• Publication Date: 2012-04-07
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.22997
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>Recent studies have shown that BRAF<sup>V600E</sup> mutation is associated with poor prognostic factors in papillary thyroid carcinoma (PTC). However, there are no studies about the association of the BRAF<sup>V600E</sup> mutation with poor prognostic factors according to tumor size in PTC.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>We investigated the prevalence of the BRAF<sup>V600E</sup> mutation and its association with prognostic factors according to tumor size of PTC. BRAF<sup>V600E</sup> mutation status was assessed in thyroid fine‐needle aspiration (FNA) specimens from 605 patients before thyroidectomy for PTC, and its association with postoperative clinicopathologic factors was evaluated.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>The overall prevalence of the BRAF<sup>V600E</sup> mutation was 67%, and larger tumors more often had the BRAF<sup>V600E</sup> mutation (<italic>p</italic> for trend < .05). The BRAF<sup>V600E</sup> mutation was significantly associated with male sex, tumor size, extrathyroidal invasion, nodal metastasis, and advanced tumor stage (<italic>p</italic> < .05). There was a significant size‐dependent relationship between the presence of the BRAF<sup>V600E</sup> mutation and extrathyroidal invasion, nodal metastasis, and advanced tumor stage (<italic>p</italic> for trend < .05).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion</title> <p>The prevalence of the BRAF<sup>V600E</sup> mutation increased with increased tumor size. Preoperative FNA‐detected BRAF<sup>V600E</sup> mutation was associated with poor prognostic factors, and the association was stronger in larger tumors. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</p> </sec> </abstract>