Elevated gastrin‐releasing peptide receptor mRNA expression in buccal mucosa: Association with head and neck squamous cell carcinoma. Issue 2 (20th March 2012)

• Record Type: Journal Article
• Authors: Egloff, Ann Marie; Liu, Xuwan; Davis, Autumn L. Gaither; Trevelline, Brian K.; Vuga, Marike; Siegfried, Jill M.; Grandis, Jennifer R.
• Is Part Of: Head & neck. Volume 35:Issue 2(2013:Feb.)
• Page Start: 270
• Page End: 279
• Publication Date: 2012-03-20
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.22963
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>Expression of gastrin‐releasing peptide receptor (<italic>GRPR</italic>) is elevated in mucosa adjacent to head and neck squamous cell carcinoma (HNSCC) compared with mucosa from cancer‐free controls, suggesting elevated <italic>GRPR</italic> expression may indicate presence of HNSCC.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>We measured <italic>GRPR</italic> mRNA levels in histologically normal buccal mucosa from 65 surgical patients with HNSCC and 75 cancer‐free control subjects using quantitative polymerase chain reaction (PCR). We tested for association between <italic>GRPR</italic> expression and HNSCC and evaluated differences in patient progression‐free survival (PFS).</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>Buccal <italic>GRPR</italic> expression was higher in cases but not controls who were active smokers (<italic>p</italic> = .04). High <italic>GRPR</italic> expression was associated with HNSCC (odds ratio [OR] = 3.55; 95% confidence interval [CI] = 1.15–10.93), even after adjustment for age, sex, tobacco use, and sample storage time. PFS did not differ between patients with HNSCC with high versus low <italic>GRPR</italic> expression (<italic>p</italic> = .22).</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusion</title> <p>Elevated buccal <italic>GRPR</italic> expression was significantly associated with HNSCC independent of known risk factors but was not an indicator of disease prognosis. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</p> </sec> </abstract>