Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta‐analysis of trends by time and region. Issue 5 (20th January 2012)

• Record Type: Journal Article
• Authors: Mehanna, Hisham; Beech, Tom; Nicholson, Tom; El‐Hariry, Iman; McConkey, Christopher; Paleri, Vinidh; Roberts, Sally; Eisele, David W.
• Is Part Of: Head & neck. Volume 35:Issue 5(2013:May)
• Page Start: 747
• Page End: 755
• Publication Date: 2012-01-20
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.22015
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background</title> <p>Little information has been reported on regional and time trends of human papillomavirus (HPV) prevalence rates of oropharyngeal cancer (OPC) and non‐OPC.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Methods</title> <p>The study consisted of a systematic review and meta‐analysis using random effects logistic regression models.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results</title> <p>Overall HPV prevalence in OPC (47.7%; 95% confidence interval [CI], 42.9–52.5%) increased significantly over time: from 40.5% (95% CI, 35.1–46.1) before 2000, to 64.3% (95% CI, 56.7–71.3) between 2000 and 2004, and 72.2% (95% CI, 52.9–85.7) between 2005 and 2009 (<italic>p</italic> < .001). Prevalence increased significantly in North America and Europe, and the significant gap between them that existed before 2000 (50.7% vs 35.3%, respectively, <italic>p</italic> = .008) has now disappeared (69.7% vs 73.1%, respectively, <italic>p</italic> = .8). Prevalence in non‐OPC (21.8%; 95% CI, 18.9–25.1%) has not increased over time (<italic>p</italic> = .97)</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions</title> <p>The sharp increase in the proportion of HPV‐positive OPC over the last decade has occurred at a faster rate in Europe compared with that in North America. In contrast, the relatively low prevalence of HPV in non‐OPC remains unchanged. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</p> </sec> </abstract>