The Synthesis of N, N‐Bis(dialkoxyphosphinoylmethyl)‐ and N, N‐Bis(diphenylphosphinoylmethyl)glycine Esters by the Microwave‐Assisted Double Kabachnik–Fields Reaction. Issue 6 (31st October 2013)

• Record Type: Journal Article
• Authors: Bálint, Erika; Fazekas, Eszter; Drahos, László; Keglevich, György
• Is Part Of: Heteroatom chemistry. Volume 24:Issue 6(2013:Nov.)
• Page Start: 510
• Page End: 515
• Publication Date: 2013-10-31
• Subjects: Heterocyclic chemistry -- Periodicals; 547.59
• DOI: 10.1002/hc.21126
• Languages: English
• ISSNs: 1042-7163

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha‐Mannich) products under microwave (MW) conditions at 100°C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent‐free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency.</p> </abstract>