Classical and unconventional pathways of vesicular release in microglia. Issue 7 (26th April 2013)

• Record Type: Journal Article
• Authors: Prada, Ilaria; Furlan, Roberto; Matteoli, Michela; Verderio, Claudia
• Is Part Of: Glia. Volume 61:Issue 7(2013:Jul.)
• Page Start: 1003
• Page End: 1017
• Publication Date: 2013-04-26
• Subjects: Neuroglia -- Periodicals; Neurology -- Periodicals; 611.0188
• DOI: 10.1002/glia.22497
• Languages: English
• ISSNs: 0894-1491

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Emerging evidence indicates that activation of microglia, the immune cells of the brain, is strictly associated to both secretion of soluble molecules and release of <bold>extracellular</bold> membrane vesicles (EMVs) into the <bold>pericellular</bold> space. Through these processes, microglia heavily influence brain cell functions, either propagating inflammation and causing damage to neurons or playing a supportive, neuroprotective role. In this review, we highlight the emerging concepts related to <bold>vesicular</bold> mechanisms <bold>of secretion</bold> operating in microglial cells, with the aim of dissecting how microglia communicate with other cell types within the brain microenvironment in health and disease.</p> </abstract>