High frequency of MYC gene amplification is a common feature of radiation‐induced sarcomas. Further results from EORTC STBSG TL 01/01. Issue 1 (25th September 2012)

• Record Type: Journal Article
• Authors: Käcker, Christoph; Marx, Alexander; Mössinger, Katharina; Svehla, Frederike; Schneider, Ulrike; Hogendoorn, Pancras Cornelis Wilhelmus; Nielsen, Ole Steen; Küffer, Stefan; Sauer, Christian; Fisher, Cyril; Hallermann, Christian; Hartmann, Jörg Thomas; Blay, Jean‐Yves; Mechtersheimer, Gunhild; Hohenberger, Peter; Ströbel, Philipp
• Is Part Of: Genes, chromosomes & cancer. Volume 52:Issue 1(2013:Jan.)
• Page Start: 93
• Page End: 98
• Publication Date: 2012-09-25
• Subjects: Cancer -- Genetic aspects -- Periodicals; 616.994042
• DOI: 10.1002/gcc.22009
• Languages: English
• ISSNs: 1045-2257

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Irradiation is a major causative factor among the small subgroup of sarcomas with a known etiology. The prognosis of radiation‐induced sarcomas (RIS) is significantly worse than that of their spontaneous counterparts. The most frequent histological subtypes include undifferentiated pleomorphic sarcomas, angiosarcomas, and leiomyosarcomas. A high frequency of <italic>MYC</italic> amplifications in radiation‐induced angiosarcomas, but not in primary angiosarcomas, has recently been described. To investigate whether <italic>MYC</italic> amplifications are also frequent in RIS other than angiosarcomas, we analyzed the <italic>MYC</italic> amplification status of 83 RIS and 192 sporadic sarcomas by fluorescence in situ hybridization. We found significantly higher numbers of <italic>MYC</italic> amplifications in RIS than in sporadic sarcomas (<italic>P</italic> &lt; 0.0001), especially in angiosarcomas, undifferentiated pleomorphic sarcomas, and leiomyosarcomas. Angiosarcomas were special in that <italic>MYC</italic> amplifications were particularly frequent and always high level, while other RIS showed low‐level amplifications. We conclude that <italic>MYC</italic> amplifications are a frequent feature of RIS as a group and may contribute to the biology of these tumors. © 2012 Wiley Periodicals, Inc.</p> </abstract>