Molecular and genomic aberrations in Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas. Issue 9 (23rd July 2013)

• Record Type: Journal Article
• Authors: Zhu, Daxing; Ikpatt, Offiong F.; Dubovy, Sander R.; Lossos, Chen; Natkunam, Yasodha; Chapman‐Fredricks, Jennifer R.; Fan, Yao‐Shan; Lossos, Izidore S.
• Is Part Of: American journal of hematology. Volume 88:Issue 9(2013:Sep.)
• Page Start: 730
• Page End: 735
• Publication Date: 2013-07-23
• Subjects: Hematology -- Periodicals; 616.15
• DOI: 10.1002/ajh.23490
• Languages: English
• ISSNs: 0361-8609

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The etiology and pathogenesis of ocular adnexal extranodal marginal zone lymphoma (OAEMZL) are still unknown and the association with <italic>Chlamydophila psittaci (C. psittaci</italic>) has been shown in only some geographic regions. Herein, we comprehensively examined the frequency of chromosomal translocations as well as CARD11, MYD88 (L265P), and A20 mutations/deletions in 45 <italic>C. psittaci</italic> negative OAEMZLs. t(14;18)(q32;q21) IGH‐MALT1 and t(11;18)(q21;q21) API2‐MALT1 were not detected in any of the analyzed tumors while three tumors harbored <italic>IGH</italic> translocations to an unidentified partner. CARD11 mutations were not found in all analyzed tumors, while the MYD88 L265P mutation was detected in three (6.7%) tumors. A20 mutations and deletions were each detected in seven (15.6%) and six (13.3%) tumors, respectively. Therefore, the observed genetic aberrations could account for the activation of the nuclear factor (NF)‐kB signaling pathway in only a minority of the cases. Further studies are needed to identify the molecular mechanisms underlying the pathogenesis of OAEMZL. Am. J. Hematol. 88:730–735, 2013. © 2013 Wiley Periodicals, Inc.</p> </abstract>