A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL‐10 dependent derivatives of inflammatory monocytes. Issue 4 (2nd April 2013)

• Record Type: Journal Article
• Authors: Fevre, Cindy; Almeida, Ana S.; Taront, Solenne; Pedron, Thierry; Huerre, Michel; Prevost, Marie‐Christine; Kieusseian, Aurélie; Cumano, Ana; Brisse, Sylvain; Sansonetti, Philippe J.; Tournebize, Régis
• Is Part Of: EMBO molecular medicine. Volume 5:Issue 4(2013:Apr.)
• Page Start: 516
• Page End: 530
• Publication Date: 2013-04-02
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.1002/emmm.201202023
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Rhinoscleroma is a human specific chronic disease characterized by the formation of granuloma in the airways, caused by the bacterium <italic>Klebsiella pneumoniae</italic> subspecies <italic>rhinoscleromatis</italic>, a species very closely related to <italic>K. pneumoniae</italic> subspecies <italic>pneumoniae</italic>. It is characterized by the appearance of specific foamy macrophages called Mikulicz cells. However, very little is known about the pathophysiological processes underlying rhinoscleroma. Herein, we characterized a murine model recapitulating the formation of Mikulicz cells in lungs and identified them as atypical inflammatory monocytes specifically recruited from the bone marrow upon <italic>K. rhinoscleromatis</italic> infection in a CCR2‐independent manner. While <italic>K. pneumoniae</italic> and <italic>K. rhinoscleromatis</italic> infections induced a classical inflammatory reaction, <italic>K. rhinoscleromatis</italic> infection was characterized by a strong production of IL‐10 concomitant to the appearance of Mikulicz cells. Strikingly, in the absence of IL‐10, very few Mikulicz cells were observed, confirming a crucial role of IL‐10 in the establishment of a proper environment leading to the maturation of these atypical monocytes. This is the first characterization of the environment leading to Mikulicz cells maturation and their identification as inflammatory monocytes.</p> </abstract>