Electrochemical Determination of the Anticancer Herbal Drug Shikonin at a Nanostructured Poly(hydroxymethylated‐3, 4‐ethylenedioxythiophene) Modified Electrode. Issue 9 (27th August 2013)

• Record Type: Journal Article
• Authors: Wu, Liping; Lu, Limin; Zhang, Long; Xu, Jingkun; Zhang, Kaixin; Wen, Yangping; Duan, Xuemin; Yang, Fan
• Is Part Of: Electroanalysis. Volume 25:Issue 9(2013:Sep.)
• Page Start: 2244
• Page End: 2250
• Publication Date: 2013-08-27
• Subjects: Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201300247
• Languages: English
• ISSNs: 1040-0397

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti‐tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated‐3, 4‐ethylenedioxy‐thiophene) (PEDOT‐MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3, 4‐ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT‐MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT‐MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0 nM to 10.0 µM with detection limit of 0.3 nM. Furthermore, the PEDOT‐MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin.</p> </abstract>