Adsorption and Electrooxidation of Nucleic Acids at Glassy Carbon Electrodes Modified with Multiwalled Carbon Nanotubes Dispersed In Polylysine. Issue 5 (5th March 2013)

• Record Type: Journal Article
• Authors: Jalit, Yamile; Moreno, Mónica; Gutierrez, Fabiana A.; Sanchez Arribas, Alberto; Chicharro, Manuel; Bermejo, Esperanza; Zapardiel, Antonio; Parrado, Concepción; Rivas, Gustavo A.; Rodríguez, Marcela C.
• Is Part Of: Electroanalysis. Volume 25:Issue 5(2013:May)
• Page Start: 1116
• Page End: 1121
• Publication Date: 2013-03-05
• Subjects: Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201200622
• Languages: English
• ISSNs: 1040-0397

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>We report the advantages of the adsorption and electrooxidation of oligonucleotides and calf‐thymus double stranded DNA (dsDNA) at glassy carbon electrodes (GCE) modified with a dispersion of multiwalled carbon nanotubes (MWCNT) in poly‐<sc>L</sc>‐lysine (Plys) (GCE/MWCNT‐Plys). Important enhancement in the guanine oxidation signal was obtained by adsorptive stripping voltammetry (AdSV) due to a most favorable interaction between the negatively charged DNAs and the positively charged Plys that support the MWCNT. The layer of oligo(dG)₁₁ immobilized at GCE/MWCNT‐Plys was successfully used for the selective detection of the hybridization event using oligo(dG)₁₁/oligo(dC)₁₁ as model.</p> </abstract>