Β‐Cyclodextrin‐Functionalized Gold Nanoparticles/Poly(L‐cysteine) Modified Glassy Carbon Electrode for Sensitive Determination of Metronidazole. Issue 5 (21st March 2013)

• Record Type: Journal Article
• Authors: Gu, Yue; Liu, Weilu; Chen, Ruixue; Zhang, Li; Zhang, Zhiquan
• Is Part Of: Electroanalysis. Volume 25:Issue 5(2013:May)
• Page Start: 1209
• Page End: 1216
• Publication Date: 2013-03-21
• Subjects: Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201200529
• Languages: English
• ISSNs: 1040-0397

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A simple electrochemical method was developed to determine metronidazole based on <italic>β</italic>‐cyclodextrin‐functionalized gold nanoparticles/poly(<sc>L</sc>‐cysteine) modified glassy carbon electrode (<italic>β</italic>‐CD‐GNPs/poly(<sc>L</sc>‐cys)/GCE). The electropolymerized film of poly(<sc>L</sc>‐cys) provides a stable matrix for the fabrication of a sensing interface. <italic>β</italic>‐CD‐GNPs can form inclusion complexes with metronidazole and act as a modifier with catalytic function. The modified electrode exhibited excellent electrocatalytic activity towards metronidazole. The reaction of metronidazole at the modified electrode was an irreversible process controlled by diffusion. Under optimum experimental conditions, the logarithm of catalytic currents shows a good linear relationship with that of the metronidazole concentration in the range of 0.1–600 µmol/L with a low detection limit of 14 nmol/L. In addition, the modified electrode exhibited satisfactory stability, sensitivity and reproducibility, and could be applied to the determination of metronidazole in an injection solution.</p> </abstract>