Inside Cover: Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series (ChemMedChem 3/2013). Issue 3 (22nd February 2013)

• Record Type: Journal Article
• Authors: Goudreau, Nathalie; Coulombe, René; Faucher, Anne‐Marie; Grand‐Maître, Chantal; Lacoste, Jean‐Eric; Lemke, Christopher T.; Malenfant, Eric; Bousquet, Yves; Fader, Lee; Simoneau, Bruno; Mercier, Jean‐François; Titolo, Steve; Mason, Stephen W.
• Is Part Of: ChemMedChem. Volume 8:Issue 3(2013:Mar.)
• Page Start: 346
• Page End: 346
• Publication Date: 2013-02-22
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201390006
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Mature HIV‐1 capsid (CA) core is characterized by a fullerene cone‐shaped structure made of hexamers and pentamers. Inhibition of its assembly is a novel mechanism through which to target HIV‐1. <bold>The inside cover picture shows</bold> the characterization of potent CA assembly inhibitors (orange) as N‐terminal domain (NTD) binders using ¹⁹F NMR and X‐ray co‐crystallography. For more details, see the Full Paper by Nathalie Goudreau, René Coulombe et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 405 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1tstqkz3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>