Metal‐Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes. Issue 10 (23rd August 2013)

• Record Type: Journal Article
• Authors: Colotti, Gianni; Ilari, Andrea; Fiorillo, Annarita; Baiocco, Paola; Cinellu, Maria Agostina; Maiore, Laura; Scaletti, Federica; Gabbiani, Chiara; Messori, Luigi
• Is Part Of: ChemMedChem. Volume 8:Issue 10(2013:Oct.)
• Page Start: 1634
• Page End: 1637
• Publication Date: 2013-08-23
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201300276
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Picking a fight with parasites!</bold> Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold‐containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3j1nkj7c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>