Cover Picture: From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties (ChemMedChem 6/2013). Issue 6 (24th May 2013) - Buscató, Estel.la
Abstract The front cover picture shows the structure of the multipotent bacterial isopropylstilbene identified as a novel soluble epoxide hydrolase (sEH) inhibitor with antiproliferative properties. This natural product served as a template for the design and synthesis of (E)‐styryl‐1H‐benzo[d]imidazoles—easily accessible compounds with enhanced activity towards sEH. The modeled conformation of one of the designed compounds is shown in the foreground, and the background displays apoptotic cells after treatment with isopropylstilbene. For more details, see the Communication by Ewgenij Proschak et al. on p. 919 ff.