From In Situ to In Vivo: An In Situ Click‐Chemistry‐Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography. Issue 1 (3rd December 2012)

• Record Type: Journal Article
• Authors: Mocharla, Vani P.; Walsh, Joseph C.; Padgett, Henry C.; Su, Helen; Fueger, Barbara; Weber, Wolfgang A.; Czernin, Johannes; Kolb, Hartmuth C.
• Is Part Of: ChemMedChem. Volume 8:Issue 1(2013:Jan.)
• Page Start: 43
• Page End: 48
• Publication Date: 2012-12-03
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201200466
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>CA II makes a good PET:</bold> Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses ¹⁹F‐bearing fragments as ¹⁸F surrogates. This ensures that the lead hits and PET probes have equivalent chemical or biological characteristics, making PET probe discovery predictable and reliable.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p89bcjm" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>