Synthesis of 3, 4‐Disubstituted Quinolin‐2‐(1H)‐ones via Palladium‐Catalyzed Decarboxylative Arylation Reactions. Issue 10 (12th July 2013)

• Record Type: Journal Article
• Authors: Carrër, Amandine; Brion, Jean‐Daniel; Messaoudi, Samir; Alami, Mouad
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 10(2013)
• Page Start: 2044
• Page End: 2054
• Publication Date: 2013-07-12
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201300299
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The Pd‐catalyzed decarboxylative cross‐coupling reaction of 4‐substituted quinolin‐2(1<italic>H</italic>)‐one‐3‐carboxylic acids with (hetero)aryl halides is described. With palladium(II) bromide and triphenylarsine ligand as the catalyst system, a variety of 4‐substituted 3‐(hetero)aryl quinolin‐2(1 <italic>H</italic>)‐ones and related heterocycles, such as 4‐substituted 3‐arylcoumarins can be prepared in good to excellent yields.</p> </abstract>