Palladium‐Catalyzed Route to Three‐Component, One‐Pot Sequential Synthesis of Functionalized Cyclazines: 2, 2a1, 4‐Triazacyclopenta[cd]indenes. Issue 10 (12th July 2013)

• Record Type: Journal Article
• Authors: Yang, Anjiang; Jiang, Ruwei; Khorev, Oleg; Yu, Ting; Zhang, Yongliang; Ma, Lanping; Chen, Guohua; Shen, Jingkang; Meng, Tao
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 10(2013)
• Page Start: 1984
• Page End: 1988
• Publication Date: 2013-07-12
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201300309
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An efficient tandem route to the synthesis of 2, 2a¹, 4‐triazacyclopenta[<italic>cd</italic>]indene derivatives of the cyclazine family has been developed. The target compounds were obtained in moderate to good yields by an ytterbium(III) triflate/palladium(II) acetate‐catalyzed three‐component domino reaction involving a palladium‐catalyzed intramolecular α‐arylation of an α‐aminocarbonyl functionality. This in turn will set the stage for a wide application of this useful reaction for the synthesis of structurally diverse polyheterocyclic skeletons containing the privileged imidazo[1, 2‐<italic>a</italic>]pyridine structure.</p> </abstract>