Improvement of Arterial Stiffness in the Transition From Acute Decompensated Heart Failure to Chronic Compensated Heart Failure. Issue 6 (12th April 2013)

• Record Type: Journal Article
• Authors: Kim, Dong‐Bin; Baek, Sang Hong; Jang, Sung Won; Her, Sung‐Ho; Shin, Dong‐Il; Park, Chan Seok; Park, Hoon Joon; Kim, Pum Joon; Jung, Hae Ok; Seung, Ki Bae
• Is Part Of: Clinical cardiology. Volume 36:Issue 6(2013:Jun.)
• Page Start: 358
• Page End: 362
• Publication Date: 2013-04-12
• Subjects: Cardiology -- Periodicals; 616.12005
• DOI: 10.1002/clc.22127
• Languages: English
• ISSNs: 0160-9289

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="clc22127-sec-0001" sec-type="section"> <title>Background</title> <p>Pulse wave velocity (PWV) is a well‐established marker for aortic stiffness and may be a prognostic factor in heart failure (HF). This study investigates whether PWV changes as patients transition from acute decompensated heart failure (ADHF) to chronic compensated heart failure (CCHF).</p> </sec> <sec id="clc22127-sec-0002" sec-type="section"> <title>Hypothesis</title> <p>Arterial stiffness is related with the development of HF.</p> </sec> <sec id="clc22127-sec-0003" sec-type="section"> <title>Methods</title> <p>Regional PWV was prospectively measured using noninvasive applanation tonometry in consecutive ADHF patients (n = 55). PWV measurements of 45 patients were taken at admission and 3‐month follow‐up (F/U).</p> </sec> <sec id="clc22127-sec-0004" sec-type="section"> <title>Results</title> <p>Central and upper‐extremity PWV, but not lower‐extremity PWVs, were found to have improved after 3 months compared with the admission PWV (central: 8.73 ± 1.17 vs 8.39 ± 0.99 m/s, <italic>P =</italic> 0.018; upper extremity: 8.59 ± 0.84 vs 8.33 ± 0.82 m/s, <italic>P</italic> = 0.028). Multivariate logistic regression analyses revealed that low‐density lipoprotein cholesterol was significantly associated with the change of PWV in HF (odds ratio: 1.037, 95% confidence interval: 1.003‐1.071, <italic>P</italic> = 0.030). In preserved left ventricular ejection fraction patients (n = 26) and ischemic patients (n = 31), central and upper‐extremity PWVs improved over the admission PWV at 3‐month F/U.</p> </sec> <sec id="clc22127-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The present results indicate that central and upper‐extremity PWVs, but not lower‐extremity PWV, are increased in ADHF and improve as patients transition from ADHF to CCHF.</p> </sec> </abstract>