Impact of Lesion Length on Functional Significance in Intermediate Coronary Lesions. Issue 3 (6th November 2012)

• Record Type: Journal Article
• Authors: Iguchi, Tomokazu; Hasegawa, Takao; Nishimura, Satoshi; Nakata, Shinji; Kataoka, Toru; Ehara, Shoichi; Hanatani, Akihisa; Shimada, Kenei; Yoshiyama, Minoru
• Is Part Of: Clinical cardiology. Volume 36:Issue 3(2013:Mar.)
• Page Start: 172
• Page End: 177
• Publication Date: 2012-11-06
• Subjects: Cardiology -- Periodicals; 616.12005
• DOI: 10.1002/clc.22076
• Languages: English
• ISSNs: 0160-9289

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background:</title> <p>Myocardial fractional flow reserve (FFR) is useful in the evaluation of coronary lesion ischemia. However, the impact of lesion length on FFR has not been adequately assessed.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Hypothesis:</title> <p>We hypothesized that lesion length would influence functional significance in intermediate coronary lesions.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Methods:</title> <p>FFR measurements were assessed in 136 patients (163 lesions) with stable angina who had >40% stenotic coronary lesion by quantitative coronary angiography (QCA). One hundred sixty‐three lesions were classified as intermediate (40%–70% stenosis; n=107; group I) or significant (≥70%; n=56; group S) by QCA. We assessed the relationships between lesion length, coronary stenosis, and FFR in these 163 lesions.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Results:</title> <p>Regression analysis revealed an inverse correlation between the percentage of diameter stenosis (%DS) and FFR in group S (<italic>r</italic> = −0.83, <italic>P <</italic> 0.0001). In group I, no significant correlation was found between %DS and FFR (<italic>r</italic> = −0.06, <italic>P</italic> = 0.55), whereas lesion length was significantly inversely correlated with FFR (<italic>r</italic> = −0.79, <italic>P <</italic> 0.0001). Receiver operating characteristic curve analysis demonstrated that the best cutoff value for predicting an FFR value <0.80 was a lesion length >16.1 mm in group I (sensitivity, 86%; specificity, 94%).</p> </sec> <sec id="abs1-5" sec-type="section"> <title>Conclusions:</title> <p>These study findings suggest that lesion length has a physiologically significant impact on intermediate‐grade coronary lesions. <italic>Clin. Cardiol.</italic> 2011 DOI: 10.1002/clc.22076</p> <p>The authors have no funding, financial relationships, or conflicts of interest to disclose.</p> </sec> </abstract>