Number of Leads With Fragmented QRS Predicts Response to Cardiac Resynchronization Therapy. Issue 1 (18th October 2012)

• Record Type: Journal Article
• Authors: Celikyurt, Umut; Agacdiken, Aysen; Sahin, Tayfun; Al, Neslihan; Kozdag, Guliz; Vural, Ahmet; Ural, Dilek
• Is Part Of: Clinical cardiology. Volume 36:Issue 1(2013:Jan.)
• Page Start: 36
• Page End: 39
• Publication Date: 2012-10-18
• Subjects: Cardiology -- Periodicals; 616.12005
• DOI: 10.1002/clc.22061
• Languages: English
• ISSNs: 0160-9289

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background:</title> <p>Cardiac resynchronization therapy (CRT) is an effective option in the treatment of patients with heart failure (HF) and wide QRS. Fragmented QRS (fQRS) on 12‐lead electrocardiography has been shown to predict cardiac events in several patient populations. However, the relationship between the number of leads with fQRS and response to CRT has not been investigated.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Hypothesis:</title> <p>The number of leads with fQRS may predict response to CRT.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Methods:</title> <p>One hundred five patients with HF undergoing CRT were prospectively studied. The presence of fQRS was assessed using standardized criteria. Echocardiographic response to CRT was defined by a ≥15% reduction in left ventricular end‐systolic volume at 6 months follow‐up.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Results:</title> <p>Seventy‐four patients (71%) had CRT response after 6 months of follow‐up. In multivariate analysis, significant associates of response to CRT were evaluated adjusting for gender, etiology of cardiomyopathy, QRS width, baseline left ventricular ejection fraction, and the number of leads with fQRS. The number of leads with fQRS was the only predictor of response to CRT (odds ratio: 0.61, 95% confidence interval: 0.48‐0.77, <italic>P <</italic> 0.001).</p> </sec> <sec id="abs1-5" sec-type="section"> <title>Conclusions:</title> <p>The more leads with fQRS predicts nonresponse to CRT and may help in the selection of CRT candidates. <italic>Clin. Cardiol.</italic> 2011 DOI: 10.1002/clc.22061</p> <p>The authors have no funding, financial relationships, or conflicts of interest to disclose.</p> </sec> </abstract>