Comparison of the Seattle Heart Failure Model and Cardiopulmonary Exercise Capacity for Prediction of Death in Patients With Chronic Ischemic Heart Failure and Intracoronary Progenitor Cell Application. Issue 3 (3rd February 2013)

• Record Type: Journal Article
• Authors: Honold, Joerg; DeRosa, Salvatore; Spyridopoulos, Ioakim; Fischer‐Rasokat, Ulrich; Seeger, Florian H.; Leistner, David; Lotz, Saskia; Levy, Wayne C.; Zeiher, Andreas M.; Assmus, Birgit
• Is Part Of: Clinical cardiology. Volume 36:Issue 3(2013:Mar.)
• Page Start: 153
• Page End: 159
• Publication Date: 2013-02-03
• Subjects: Cardiology -- Periodicals; 616.12005
• DOI: 10.1002/clc.22093
• Languages: English
• ISSNs: 0160-9289

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Background:</title> <p>Despite many therapeutic advances, the prognosis of patients with chronic heart failure (CHF) remains poor. Therefore, reliable identification of high‐risk patients with poor prognosis is of utmost importance. Cardiopulmonary exercise testing (CPET) provides important prognostic information by peak O<sub>2</sub> uptake (peak VO<sub>2</sub>), maximal oxygen pulse (O<sub>2</sub> Pmax), O<sub>2</sub> uptake efficiency slope (OUES), and VE/VCO<sub>2</sub> slope (VE/VCO<sub>2</sub>). A different approach for prognostic assessment is the Seattle Heart Failure Model (SHFM), which is based on clinical data and calculates the estimated annual mortality.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Hypothesis:</title> <p>Comparison of the prognostic value of the Seattle Heart Failure Score and cardiopulmonary excercis testing in patients with chronic heart failure.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Methods:</title> <p>One hundred fifty‐seven patients with ischemic heart failure and recent intracoronary progenitor cell application were analyzed for mortality during a follow‐up of 4 years. CPET (peak VO<sub>2</sub>, O<sub>2</sub> Pmax, OUES, VE/VCO<sub>2</sub>) was performed in all patients at baseline. The SHFM score was calculated for every patient, with data obtained at the time of CPET.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Results:</title> <p>During follow‐up, 24 patients died (15.2%). Nonsurvivors had significantly worse initial CPET results and a higher SHFM score compared to survivors. Receiver operating characteristics curve analysis of sensitivity and specificity revealed the largest area under the curve value for the SHFM score, followed by VE/VCO<sub>2</sub> slope. Kaplan Meier analysis using cutoff points of SHFM and VE/VCO<sub>2</sub> slope with highest sensitivity and specificity resulted in significant discrimination of survivors and nonsurvivors. By multivariate analysis, only the SHFM score persisted as independent predictor of mortality in these patients.</p> </sec> <sec id="abs1-5" sec-type="section"> <title>Conclusions:</title> <p>These data indicate superior prognostic power of the SHFM score compared to CPET in patients with chronic ischemic heart failure.</p> <p>The authors have no funding, financial relationships, or conflicts of interest to disclose.</p> </sec> </abstract>