Synthesis, Structure and H+/K+‐ATPase Inhibitory Activity of Novel Triazolyl Substituted Tetrahydrobenzofuran Derivatives via One‐pot Three‐component Click Reaction. Issue 6 (29th April 2013)

• Record Type: Journal Article
• Authors: Fang, Hubiao; Jin, Lei; Huang, Nianyu; Wang, Junzhi; Zou, Kun; Luo, Zaigang
• Is Part Of: Chinese journal of chemistry. Volume 31:Issue 6(2013:Jun.)
• Page Start: 831
• Page End: 836
• Publication Date: 2013-04-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201300119
• Languages: English
• ISSNs: 1001-604X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Eleven triazolyl substituted tetrahydrobenzofuran derivatives were synthesized in high yields as novel H⁺/K⁺‐ATPase inhibitor via one‐pot CuI‐catalyzed three‐component click reaction of azide, secondary amine and 3‐bromopropyne under mild conditions in water. Their structures were characterized by NMR, IR, ESI‐MS, elemental analysis and single‐crystal X‐ray diffraction analysis. Most of the target compounds exhibited better H⁺/K⁺‐ATPase inhibitory activity than commercial omeprazole with IC₅₀ values less than 15 µmol·L⁻¹. The initial structure‐activity analysis suggested that the triazole substituted by cycloalkyl, aromatic ring or <italic>O</italic>‐containing side‐chain seemed to be beneficial for enhancing the activity.</p> </abstract>