Synthesis and Cytotoxic Evaluation of Novel Platinum(II) Complexes with C2‐Asymmetric and C2‐Symmetric Chiral Vicinal Diamines. Issue 1 (8th January 2013)

• Record Type: Journal Article
• Authors: Zhang, Chen; Liu, Hongrui; Yang, Qing; Chang, Jun; Sun, Xun
• Is Part Of: Chinese journal of chemistry. Volume 31:Issue 1(2013:Jan.)
• Page Start: 154
• Page End: 158
• Publication Date: 2013-01-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201201168
• Languages: English
• ISSNs: 1001-604X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A series of new platinum(II) complexes with <italic>C</italic><sub>2</sub>‐asymmetric and <italic>C</italic><sub>2</sub>‐symmetric 1, 2‐diamines were designed and synthesized by convenient methods, involving samarium diiodide induced reductive coupling as the key step. The results of cytotoxicity showed that compounds (<italic>R</italic>, <italic>R</italic>)‐<bold>11a </bold>and (<italic>S</italic>, <italic>S</italic>)‐<bold>11a</bold>, two novel platinum(II) complexes with asymmetric 1, 2‐diamines, exhibited more potent cytotoxicity than that of oxaliplatin against all leukemia cell lines. Interestingly, (<italic>R</italic>, <italic>R</italic>)‐<bold>11a </bold>and (<italic>S</italic>, <italic>S</italic>)‐<bold>11a</bold> demonstrated less potent activity against three solid cancer cell lines than that of oxaliplatin, which indicated that these two compounds may only selectively inhibit the leukemia cell lines. In contrast, (<italic>R</italic>, <italic>R</italic>)‐<bold>15a </bold>and (<italic>S</italic>, <italic>S</italic>)‐<bold>15a</bold>, two platinum(II) complexes with symmetric 1, 2‐diamines, showed similar cytotoxicity to that of oxaliplatin against all leukemia cell lines and more potent activity against solid cancer cell lines. Further flow cytometry data indicated that (<italic>R</italic>, <italic>R</italic>)‐<bold>11a </bold>could obviously arrest leukemia K562 cells in G2/M phases.</p> </abstract>