First Total Synthesis of the Proposed Structures of Orisuaveolines A and B. Issue 1 (8th January 2013)

• Record Type: Journal Article
• Authors: Zhang, Jie; Da, Shijun; Feng, Xiaolin; Chen, Xiaoyi; Jiang, Jianhui; Li, Ying
• Is Part Of: Chinese journal of chemistry. Volume 31:Issue 1(2013:Jan.)
• Page Start: 123
• Page End: 126
• Publication Date: 2013-01-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201200986
• Languages: English
• ISSNs: 1001-604X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>First total synthesis of the proposed structures of <italic>β</italic>‐indoloquinazoline alkaloids orisuaveolines A and B is reported. The key steps of the synthesis included a Pictet‐Spengler reaction to build a six‐member lactam which further transformed into target molecular by a one‐pot condensation. This synthesis provided an access to the proposed structures of orisuaveolines A and B in a short and convenient manner from inexpensive, commercially available starting materials. The structures of our synthesized products were confirmed by 2D‐NMR experiments.</p> </abstract>