Double Gold‐Catalysed Annulation of Indoles by Enynones. Issue 6 (9th April 2013)

• Record Type: Journal Article
• Authors: Heffernan, Stephen J.; Tellam, James P.; Queru, Marine E.; Silvanus, Andrew C.; Benito, David; Mahon, Mary F.; Hennessy, Alan J.; Andrews, Benjamin I.; Carbery, David R.
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 6(2013)
• Page Start: 1149
• Page End: 1159
• Publication Date: 2013-04-09
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201300018
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The gold‐catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles <italic>via</italic> a double sodium tetrachloroaurate‐catalysed process involving a mixture of CH activation and alkyne activation modes of promotion. Good yields for the formation of medicinally relevant [6, 5, 7]‐tricyclic indoles are realised.</p> </abstract>