Catalytic Enantioselective Addition of Alkyl Grignard Reagents to Aliphatic Aldehydes. Issue 7 (30th April 2013)

• Record Type: Journal Article
• Authors: Fernández‐Mateos, Emilio; Maciá, Beatriz; Yus, Miguel
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 7(2013)
• Page Start: 1249
• Page End: 1254
• Publication Date: 2013-04-30
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201201117
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Herein, we report an efficient catalytic system for the enantioselective addition of alkyl Grignard reagents to a broad range of aliphatic aldehydes with good yields and enantioselectivities. Remarkably, the challenging methylmagnesium bromide (MeMgBr) can also be added to a variety of aliphatic aldehydes, providing versatile chiral methyl carbinol units with unprecedented yields and enantioselectivities in a simple one‐pot procedure under mild conditions.</p> </abstract>