Stereoselective Halocyclization of Alkenes With N‐Acyl Hemiaminal Nucleophiles. Issue 11 (15th August 2013)

• Record Type: Journal Article
• Authors: Liu, Na; Wang, Hao‐Yuan; Zhang, Wei; Jia, Zhi‐Hong; Guzei, Ilia A.; Xu, Hua‐dong; Tang, Weiping
• Is Part Of: Chirality. Volume 25:Issue 11(2013:Nov.)
• Page Start: 805
• Page End: 809
• Publication Date: 2013-08-15
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22219
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Halocyclization of alkenes was realized using <italic>N</italic>‐acylhemiaminal nucleophiles. High diastereoselectivity could be achieved for the formation of three stereogenic centers in this halogen‐mediated <named-content id="d333e1099" content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">cyclization</named-content> reaction. We also demonstrated that <named-content id="d333e1102" content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">enantioselective</named-content> bromocyclization of alkenes using <italic>N</italic>‐acylhemiaminal nucleophiles was possible. <italic>Chirality 25:805–809, 2013</italic>. © 2013 Wiley Periodicals, Inc.</p> </abstract>