Cooperative Use of VCD and XRD for the Determination of Tetrahydrobenzoisoquinolines Absolute Configuration: A Reliable Proof of Memory of Chirality and Retention of Configuration in Enediyne Rearrangements. Issue 12 (13th August 2013)

• Record Type: Journal Article
• Authors: Mondal, Shovan; Naubron, Jean‐Valère; Campolo, Damien; Giorgi, Michel; Bertrand, Michéle P.; Nechab, Malek
• Is Part Of: Chirality. Volume 25:Issue 12(2013:Dec.)
• Page Start: 832
• Page End: 839
• Publication Date: 2013-08-13
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22221
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>The absolute configurations (AC) of azaheterocylic compounds resulting from the cascade <named-content id="d327e523" content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">rearrangement</named-content> of enediynes involving only light atoms were unambiguously assigned by the joint use of vibrational circular dichroism (VCD) and copper radiation single crystal X‐ray diffraction (XRD). These AC determinations proved that the <named-content id="d327e526" content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">rearrangements</named-content> of enediynes proceeded with memory of chirality and <named-content id="d327e529" content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">retention</named-content> of configuration. <italic>Chirality 25:832–839, 2013</italic>. © 2013 Wiley Periodicals, Inc.</p> </abstract>